Our name is synonymous with infertility treatment in the state of Rajasthan. Started out as a small but caring and compassionate infertility unit by Dr. Sanjay Makwana & Dr. Renu Makwana, it has now grown into a state-of-the-art high quality multi-specialty hospital possessing the latest infertility treatment modalities for IVF, ICSI, Assisted Hatching, Blastocyst transfer, Semen & Embryo Cryopreservation, fully functional Andrology lab along with facilities for genetic testing for chromosomal and genetic disorders.
Assisted reproductive technology (ART) is the technology used to achieve pregnancy in procedures such as fertility medication, artificial insemination, in vitro fertilization and surrogacy. The common word used for ART is (test tube baby treatment).
Vasundhara Hospital’s Success Rate for treating infertility has consistently proved good and varies slightly because of a variety of individual factors. We accept all cases and are known to try to help even the most difficult cases.
Our success percentages are as follows:
IUI (per treatment cycle)75%
1. IUI (Intra Uterine Inseminate)
First line of treatment of infertile couples. The semen is processed in CO2 incubator with special culture media and then the best quality sperms are placed in the uterine cavity around the time of ovulation. It is an OPD procedure and done under care of dedicated team of experts in compassionate manner. Doctors are always there to answer your queries
Common reasons for IUI:
- Low sperm count
- Decreased sperm mobility
- Unexplained infertility
- Ejaculation dysfunction
- Cervical scar tissue from past procedures which may hinder the sperm’s ability to enter the uterus
- A hostile cervical condition including cervical mucus problem/ ovulation problems
2. IVF- In Vitro Fertilization
It is the process of fertilization by manually combining an egg and sperm in a laboratory dish, and then transferring the embryo to the uterus. It is commonly known name for IVF is Test tube baby.
IVF indicated for the following patients:
- Blocked or damaged fallopian tubes
- Male factor infertility including decreased sperm count or sperm motility
- Women with ovulation disorders, premature ovarian failure, uterine fibroids
- Women who have had their fallopian tubes removed
- Endometriosis grade III and IV
- Immunologic infertility
- Unexplained infertility
- Failed IUI treatment
- Ovulation failure with all possible conventional methods
- Individuals with a genetic disorder
- Unexplained infertility
Success of IVF
It depends on a number of factors including:
- Reproductive history
- Maternal age
- Cause of infertility
- Lifestyle factors
3.Intra Cytoplasmic Sperm Injection (ICSI) :
It can be used as part of an in vitro fertilisation (IVF) treatment to help you and your spouse to conceive a child. ICSI is the most successful form of treatment for men who are infertile and is used in nearly half of all IVF treatments.
ICSI only requires one sperm, which is injected directly into the egg. The fertilised egg (embryo) is then transferred to your uterus (womb). During ICSI the sperm doesn’t have to travel to the egg or penetrate the outer layers of the egg.
This means that it can help couples where the man’s sperm:
- Can’t get to the egg at all
- Can get to the egg, but for some reason can’t fertilise it
ICSI is likely to be recommended if your spouse has:
- A very low or zero sperm count.
- A high percentage of abnormally shaped sperm. This can result in poor motility, which means the sperm can’t swim well.
- Sperm that can’t be ejaculated but can be collected from the testicles or from the duct where sperm is stored (epididymis). This may be needed if your spouse has had an irreversible vasectomy or injury.
- Problems with getting an erection and ejaculating, due to spinal cord injuries or DIABETES , for example.
If you have tried IVF you may move on to ICSI if not enough eggs could be retrieved, or if eggs retrieved for IVF were not successfully fertilised.
4. Intracytoplasmic Morphological Sperm Injection (IMSI):
Intracytoplasmic Morphological Sperm Injection (IMSI) involves inserting sperm into the egg by selecting better quality sperm and results in higher pregnancy rates as compared to conventional ICSI. The IMSI improves the chances of fertilization in vitro in cases of severe male infertility.
Indication for IMSI:
IMSI is recommended for couples when
- Sperm samples are unusually low or highly abnormal.
- For patients who have already undergone several IVF treatment cycles without success.
5. Embryo/Oocyte/ Sperm Banking:
a. Semen Banking
At our hospital following facilities are available:
- ‘Long-term’ & “short term” semen cryopreservation
- Concentration for oligozoospermia
- Standard and pre-processed sample
- Anonymous donor semen bank.
b. Egg Bank:
Women are stimulated with medicine/Injectable to produce more number of eggs. The eggs are retrieved and frozen in the lab.
- Women undergoing cancer therapy
- Women less than 35 years who wish to preserve their eggs for future use
c. Embryo Freezing:
Cryopreservation in simple language means freezing of the embryos. Eggs are fertilized in the IVF (invitro fertilisation) lab with sperm; embryos develop which are then transferred into the uterus. Successful implantation of the embryo following this fertilization process in the IVF lab (in-vitro fertilisation lab) is an extremely important variable affecting IVF success rates. Optimal success rates usually require an average transfer of two or three embryos. However, it is not unusual for 8, 10 or occasionally more eggs to be retrieved and therefore more than 3 embryos may be produced in an IVF cycle if desired. With the technique of embryo cryopreservation (embryo freezing) embryos developed but not transferred can be cryopreserved and stored for future use.
Surrogacy is when another woman carries and gives birth to a baby for the couple who want to have a child if they’re unable to have children through their own pregnancy. The carrier of the children is called a surrogate mother.
Surrogacy may be appropriate if you have a medical condition that makes it impossible or dangerous to get pregnant and to give birth.
The type of medical conditions that might make surrogacy necessary for you include : absence or malformation of the womb
- Recurrent pregnancy loss.
- Repeated in vitro fertilisation (IVF) implantation failures.
1. Assisted Hatching
Assisted hatching [AZH] is a form of embryo micro manipulation that involves the creation of an opening in the outer covering called zona pellucid of the embryo & help growing embryo to implant in the uterus. This thinning of zona can be done by three different ways chemical hatching, mechanical hatching and the latest is with diode laser technique.
Indications for assisted hatching usage
The following indications are seen in IVF cases:
- Age factor- couples having IVF with female partners age over 37
- Egg quantity & quality factor – couples in which the female’s day 3 follicle stimulating hormone level is elevated.
- Embryo quality factor – couples having IVF with poor quality embryos
- Zona factor – Couples having IVF with embryos that have a thick outer shell
- Previous failure – couples having repeated IVF failure.
2. Blastocyst Transfer
A blastocyst is an embryo that has developed for five to six days after fertilization. With blastocyst transfer; embryos are cultured in the laboratory incubator to the blastocyst stage, one or two of the best quality blastocysts are selected before they are transferred to the womb. A blastocyst must successfully attach itself to the wall of the womb for a woman to become pregnant.
Percutaneous Epididymal Sperm Aspiration (PESA) and Testicular Sperm Aspiration (TESA) are procedures used in the management of obstructive and nonobstructive azoospermia (no sperm in the ejaculate).A fine needle is passed into the tubes leading out of the testicles, or the testicles themselves, to retrieve sperm. The retrieved sperm are injected directly into an egg (ICSI) in a similar fashion to sperm retrieved from the ejaculate.This micromanipulation of a single sperm into an egg is the treatment of choice for couples with severe male factor infertility. As a result of this technique, PESA and TESA offer a simple, quick, cheap and comfortable way of accessing sperm for use in assisted reproductive procedures post vasectomy, without resorting to vasectomy reversal.
Use of PESA-TESA Sperm
Sperm retrieved are specially prepared and individually injected directly into eggs. Routine ovulation induction, egg collection, IVF/ICSI and embryo transfer are employed. To ensure that the procedure is necessary we will sometimes ask the husband/partner to produce a semen sample on the day of the egg collection. This sample will be specially prepared and may be used for injection of the eggs (ICSI) if sperm are present. If not, we proceed to surgical recovery in the form of PESA or TESA.
Microsurgical Epididymal Sperm Aspiration (MESA)
An open surgical sperm retrieval procedure that uses an operating microscopy to locate the tubules of the epididymis precisely, so that large numbers of sperm can be extracted. The procedure has an advantage over the other methods as retrieval of sperm is much higher.
4. Time lapse monitoring technology- Embryoscope:
The time lapse incubator called Embryoscope, continually monitors the embryos and indicates if they are growing properly and within set time frames. Time lapse imaging helps in choosing the embryo with the highest implantation potential.
Time-lapse embryo monitoring is a big breakthrough in IVF and can make a difference to the success rate.
- Embryos containing the incorrect amount of chromosomes in each of their cells (known as aneuploid) may divide abnormally even though they look normal to the naked eye.
- With embryo monitoring, information can be used to assess whether a normal looking embryo is indeed ‘normal’.
- With time-lapse embryo monitoring we can transfer embryos earlier in the knowledge that the best ones have been chosen.
Vasundhara IVF is one of the few centers in India to offer this technique to ART patients at a very affordable cost.
Dr. Sanjay Makwana
Chief Medical Director | A.R.T. – Head | A.R.T. Specialist & Endoscopic Surgeon
Dr. Renu Makwana
Chief Medical Director | Obstetrics & Gynecology - Head | Gynecologist & Obstetrician| Feto-Maternal Specialist
Mr. Rahul Sen
Dr. Chandra Solanki